Therapeutic Potential of Selenium and Selenium Compounds in Cervical Cancer
نویسندگان
چکیده
منابع مشابه
Selenium Compounds
Selenium is a naturally occurring substance that is toxic at high concentrations but is also a nutritionally essential element. Hydrogen selenide is the most acutely toxic selenium compound. Acute (short-term) exposure to elemental selenium, hydrogen selenide, and selenium dioxide by inhalation results primarily in respiratory effects, such as irritation of the mucous membranes, pulmonary edema...
متن کاملSelenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.
The Grx (glutaredoxin) proteins are oxidoreductases with a central function in maintaining the redox balance within the cell. In the present study, we have explored the reactions between selenium compounds and the glutaredoxin system. Selenite, GS-Se-SG (selenodiglutathione) and selenocystine were all shown to be substrates of human Grx1, implying a novel role for the glutaredoxins in selenium ...
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Oxidative stress has become an important subject for terrestrial and aquatic toxicology. The trace element selenium has been demonstrated in chemo-prevention and drug-resistance through reduction of oxidative stress. Selenium compounds could prevent damage to the unsaturated fatty acid of subcellular membranes by lipid peroxidation induced by free radicals in fish.
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Virtually all animal and cell model studies have shown Se to reduce cancer risk in non-deficient subjects. However, the largest trial, SELECT, found no protection against prostate cancer in subjects of relatively high Se status (plasma Se 136 ng/mL). Those results are not inconsistent with the NPC trial, which found supplemental Se to have no benefits for subjects with plasma Se levels >120 ng/...
متن کاملSelenium and cancer prevention.
protection selenium provides against certain cancers that I have been taking daily selenium yeast supple ments (100-400 jxg)for 4 years, I am perplexed by the selection of cancers to be studied in related doubleblind clinical trials, namely those of the liver, skin and esophagus. In 1986, I published details of in excess of 13,000 correlations between the distributions of 219 environ mental var...
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ژورنال
عنوان ژورنال: Cancer Control
سال: 2021
ISSN: 1073-2748,1073-2748
DOI: 10.1177/10732748211001808